Vector Cross-Linkers & DSPE Linkers

Written by: Melaina Mirosevic

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Vector Cross-Linkers & DSPE Linkers

Vector Laboratories Cross-Linkers &
DSPE Linkers

Now Available through SZABO-SCANDIC in Austria

We are expanding our Specialty Chemistry & Bioconjugation portfolio.

SZABO-SCANDIC is now the official distributor in Austria for Vector Laboratories’ cross-linkers, dPEG® linkers, DSPE linkers, and click chemistry reagents.

These tools enable highly controlled, bioorthogonal conjugation workflows across academia, diagnostics, and biopharma.

 

 

Precision Bioconjugation Starts with the Right Chemistry

Modern life science workflows increasingly rely on:

  • Targeted antibody conjugates
  • Lipid-functionalized nanoparticles
  • ADC & AOC development
  • Protein and oligonucleotide labeling
  • Multiplex assay systems

Vector’s chemistry portfolio is designed to support these applications with reproducibility, modularity, and scalability.

 

CuAAC-1

Why Click Chemistry?

Click chemistry has become a cornerstone of modern conjugation strategies, offering:

  • Bioorthogonality – No interference with biological systems
  • High specificity – Minimal off-target reactions
  • Fast reaction kinetics – Seconds to minutes
  • High efficiency – Excellent yields
  • Scalability – From R&D to production

Key reactive groups include:

Azide • Alkyne • DBCO • TCO • Tetrazine

 

CuAAC SPAAC TCO
Major Click Chemistry Platforms

CuAAC – Copper-Catalyzed Click Chemistry

Ideal for in vitro applications requiring highest efficiency.
Excellent yields and broad substrate compatibility.
Limitation: Copper toxicity restricts live-cell use.

SPAAC / DBCO – Strain-Promoted Click Chemistry

Copper-free and therefore suitable for live-cell and in vivo applications.
Biocompatible and modular.

IEDDA – Tetrazine-TCO Chemistry

Ultra-fast kinetics (up to 10⁶ M⁻¹s⁻¹) for rapid conjugation and in vivo workflows.

 

DPEG linkers

dPEG® Linkers – The Hidden Key to Conjugate Performance

In bioconjugation, the reactive chemistry forms the connection —
the linker determines performance

Vector Laboratories offers the only complete portfolio of monodisperse dPEG® linkers, delivering:

  • Defined molecular weight
  • Lot-to-lot reproducibility
  • Improved solubility
  • Reduced aggregation
  • Controlled hydrophilicity
  • Optimized pharmacokinetics

Available architectures include:

  • Linear
  • Branched
  • Multi-arm (Tetramer, Hexamer)
  • Cleavable linkers
  • Bioorthogonal-tagged structures
  • DSPE-dPEG lipid conjugates

 

Liposome mit PEG-Ketten und Antikoerpern
DSPE Linkers – Enabling Lipid & Nanoparticle Functionalization

DSPE-dPEG linkers are essential tools for:

  • Liposome functionalization
  • Nanoparticle surface modification
  • Targeted drug delivery systems
  • Antibody- or peptide-modified lipid constructs
  • mRNA delivery platforms

These reagents are particularly relevant for:

  • Biopharma
  • Advanced drug delivery research
  • Nanomedicine
  • Diagnostic assay development

 

Application Workflow
Designed for Diverse Scientific Workflows

Vector’s specialty chemistry portfolio supports applications such as:

  • Antibody conjugates
  • Peptide conjugates
  • Small molecule API conjugates
  • In vitro assay components
  • Protein conjugates
  • Nanoparticle systems

Broad & Deep Portfolio

Vector Laboratories combines:

  • Click chemistries
  • dPEG® linkers
  • Fluorescent dyes
  • Lipids & copolymers
  • Enzymatic labeling reagents

All major conjugation strategies from bioorthogonal, enzymatic, and cleavable chemistries to are available within one integrated portfolio.

 

Bioconjugation Workbench
Custom & Scalable

In addition to catalog products, Vector offers:

  • Custom synthesis
  • Bioconjugation services
  • Technical advisory & application enablement
  • Research to production scale manufacturing
  • Robust quality systems and reproducible processes

Now Available 

SZABO-SCANDIC provides:

  • Application-focused technical support
  • Guidance on selecting optimal click chemistry
  • Linker architecture consulting
  • Support for ADC, nanoparticle, and lipid conjugation workflows
  • Fast local communication & quotation handling

Discover Vector’s Cross-Linkers & DSPE Linkers

Or contact our team for project-specific support.